Csf2ra macrophage
WebApr 4, 2024 · CSF2-cFLiMo–derived alveolar macrophages resemble bona fide alveolar macrophages in gene expression profile, surface markers, and functional capacities, including potent self-renewal capacity, clearance of surfactant, and efferocytosis of apoptotic cells during influenza virus infection. WebCSF2RA, “Colony stimulating factor 2 receptor alpha subunit (CD116)”, is a re-ceptor for GM-CSF (granulocyte-macrophage colony-stimulating factor), and plays a vital role for proliferation, differentiation and functional activation of hematopoietic cells such as macrophages and leukocytes . The absence of [1]
Csf2ra macrophage
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WebDescription: Homo sapiens colony stimulating factor 2 receptor subunit alpha (CSF2RA), transcript variant 7, mRNA. (from RefSeq NM_001161529) RefSeq Summary (NM_001161529): The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the … WebApr 8, 2024 · Finally, Csf2ra retroviral gene transfer into Csf2ra-deficient fetal liver monocytes restored their potential to develop into bona fide alveolar macrophages in …
WebOct 18, 2024 · Klemm et al. show that resistance to CSF1R inhibition in breast cancer brain metastasis is driven by compensatory activation of the CSF2Rb–STAT5 axis in macrophages, which can be alleviated by ... WebOriginal Article Long-Term Safety and Efficacy of Gene-Pulmonary Macrophage Transplantation Therapy of PAP in Csf2ra / Mice Paritha Arumugam, 1,2Takuji Suzuki, 6 Kenjiro Shima, 1,2Cormac McCarthy, Anthony Sallese, Matthew Wessendarp, 1,2Yan Ma, Johann Meyer,5 Diane Black,1,2 Claudia Chalk, Brenna Carey, Nico Lachmann, …
WebJul 1, 2024 · Alveolar macrophages derived from fetal monocytes (FeMo-AM) are crucial for defense against respiratory viral infections. During influenza A virus (IAV) infection, FeMo-AM are depleted, but it is unclear whether this population is replenished by self-renewing FeMo-AM or by infiltration of bone marrow–derived (BMo)–AM. WebUsing Csf2rb-null mice, which develop a myeloid cell disorder identical to hereditary pulmonary alveolar proteinosis (HPAP/SMDP) in children with CSF2RA or CSF2RB mutations, Suzuki et al. (2014) showed that pulmonary macrophage transplantation (PMT) of either wildtype or Csf2rb gene-corrected macrophages without myeloablation was …
WebApr 4, 2024 · Finally, Csf2ra retroviral gene transfer into Csf2ra-deficient fetal liver monocytes restored their potential to develop into bona fide alveolar macrophages in …
WebDec 10, 2024 · Csf2ra is a receptor for GM-CSF, a growth factor that promotes survival and activation of several immune cells including macrophages , and is important in mediating tissue inflammation . Csf2ra expression is increased on phagocytic microglia following gamma oscillation mediated amyloid plaque reductions in the 5xFAD mouse model of AD … how to soak off gel polish at homeWebHuman Gene CSF2RA (uc010ncu.2) Description: Homo sapiens colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) (CSF2RA), transcript variant 11, non-coding RNA. how to soak off gel x nails at homeWebcsf2ra Granulocyte-macrophage colony-stimulating factor receptor subunit alpha; Low affinity receptor for granulocyte-macrophage colony- stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells; Belongs to the type I cytokine receptor family. novartis offices in indiaWebMar 29, 2024 · Go to complete Gene record for CSF2RA; Go to Variation Viewer for CSF2RA variants; Summary. The protein encoded by this gene is the alpha subunit of … how to soak off gel powder nailsWebDec 3, 2015 · Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) is a cytokine that regulates various cellular processes including differentiation, proliferation, survival, … how to soak off nailsWebSep 4, 2024 · Gene-PMT therapy resulted in a stable transgene integration and correction of GM-CSF signaling and functions in Csf2ra-/-macrophages in vitro and in vivo and … novartis ophthalmic samplesWebHuman Gene CSF2RA (uc004cpp.2) Description: Homo sapiens colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) (CSF2RA), transcript variant 3, mRNA. RefSeq Summary (NM_172246): novartis ophthalmology samples