WebCytoplasmic tRNA 2-thiolation protein 1 Gene CTU1 Status UniProtKB reviewed (Swiss-Prot) Organism Homo sapiens (Human) Amino acids 348 Protein existence Evidence at protein level Annotation score 4/5 Entry Feature viewer Publications External links History BLAST Download Add a publication Entry feedback Function Webcytoplasmic tRNA 2-thiolation protein 1 [EC:2.7.7.-] K14169 cytoplasmic tRNA 2-thiolation protein 2 K14171 alkyl hydroperoxide reductase 1 [EC: 1.11.1.24] K04085 tRNA 2-thiouridine synthesizing protein A [EC:2.8.1.-] K07237 tRNA 2-thiouridine synthesizing protein B K07236 tRNA 2-thiouridine synthesizing protein C K07235
UniProt
WebFunction. Plays a central role in 2-thiolation of mcm 5 S 2 U at tRNA wobble positions of tRNA (Lys), tRNA (Glu) and tRNA (Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm 5 tRNA modification by the elongator complex is required for 2-thiolation. WebProtein target information for Cytoplasmic tRNA 2-thiolation protein 1 (Chlamydomonas reinhardtii). Find diseases associated with this biological target and compounds tested … raves in seattle 2022
Cytoplasmic tRNA 2-thiolation protein 1 (cattle) - PubChem
WebCytoplasmic tRNA 2-thiolation protein 2 (Drosophila willistoni) Protein Target - PubChem Apologies, we are having some trouble retrieving data from our servers... PUGVIEW FETCH ERROR: 403 Forbidden National Center for Biotechnology Information 8600 Rockville Pike, Bethesda, MD, 20894 USA Contact Policies FOIA HHS … WebPredicted to enable tRNA binding activity. Predicted to be involved in tRNA wobble position uridine thiolation. Predicted to act upstream of or within tRNA processing. Predicted to be located in cytosol. Predicted to be part of cytosolic tRNA wobble base thiouridylase complex. Orthologous to human CTU1 (cytosolic thiouridylase subunit 1). WebJun 6, 2014 · While cytoplasmic tRNA 2-thiolation protein 1 (Tuc1/Ncs6) and ubiquitin-related modifier-1 (Urm1) are important in the 2-thiolation of 5-methoxycarbonylmethyl-2-thiouridine (mcm 5 s 2 U) at wobble uridines of tRNAs in eukaryotes, the biocatalytic roles and properties of Ncs6/Tuc1 and its homologs are poorly understood. raves in socal