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WebThe development of extended-release (XR) metformin offers some advantages over classical immediate-release (IR) metformin formulation, especially one daily dosing option and better gastrointestinal tolerance, thus improving patient adherence. [ 2, 3] Both formulations of metformin are contraindicated in patients with moderate to severe renal … WebIt's best to take metformin tablets with, or just after, your evening meal to reduce the chance of getting side effects. Swallow your metformin tablets whole with a drink of water. Do not chew them. If you're taking metformin sachets, pour the powder into a glass and add water (about 150ml). Stir it if you need to, until the water turns clear ... WebThis international, randomized, double-blind trial (NCT01864174) compared the efficacy and safety of metformin extended-release (XR) and immediate-release (IR) in patients with … deathly dark tours