WebOct 17, 2008 · P-gp consists of two NBDs and two TMDs containing 6 TM segments each (Fig. 1A).A previous study of the domains expressed as separate polypeptides showed that TMD1 co-immunoprecipitated with NBD1 whereas TMD2 co-immunoprecipitated with NBD2 ().These results predicted that TMD1-NBD1 and TMD2-NBD2 interactions were important …
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